Her research focusses on prevention, early detection and in a not yet ill body minimal invasive intervention. She develops all kind of strategies to avoid complications caused by the surgical knife such as adhesions, incisional hernia and anastomotic leakage.
To develop these strategies she works together with many national and international institutions and engineers. For example together with the University of Trieste in Italy and Aachen biomaterials were developed to decrease the occurrence of anastomotic leakage and incisional hernia.
Together with the TU Eindhoven a new gel is developed to slowly release chemotherapy in the intra-abdominal space in patients with peritoneal metastases and together with the TU Twente she helped to develop an artificial neural network to detect all kind of diseases in exhaled air.
Together with small start-up companies Nicole Bouvy develops trans-oral devices to make it possible to perform surgery through the mouth in for example the stomach. She participates in many European studies on these topics, is author on more than 200 peer reviewed articles and guidelines, and is the first female member of the executive board of the European Association of Endoscopic Surgery.
The past years she is organizing their yearly congress as chairman of the program committee.